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irrespective of subclass or type. In addition, both heavy and light chains have also variable regions that do vary substantially in amino-acid residue sequence between different types of antibody. Each variable region of a given type of antibody can act as a variable af nity binding site (antigen binding site) for the molecular recognition and binding of a complementary protein or peptide known as an antigen. Antigens are immune system stimulatory (immunogenic) compounds that mobilise the adaptive immune system in response to the formation of antibody antigen complexes. Immune system diversity is so high in effect that every possible antigen can expect to be matched by a corresponding type of antibody able to recognise and bind to this speci c antigen to the exclusion of all others, resulting in a completely speci c immune response to this antigen. Such selectivity requires that the antibody type diversity of the immune system must exceed 1012 . The chemical biology reader can only marvel that so much diversity in molecular recognition and binding behaviour is possible as a consequence of multiple subtle variations in the amino-acid residue compositions of different antibody variable regions! Remarkably in the case of the normal functioning of the immune system, self-proteins and peptides do not normally become immune stimulatory antigens, but in autoimmune diseases they do. One such example is myasthenia gravis (MG), in which antibodies are generated that target peptide regions (epitopes) on the AChR protein, causing destruction of the protein and loss of neuronal cell function (Figure 7.5). If only the process of molecular recognition and binding could be adequately understood in this case, then the ravaging consequences of this

The second argument for the VLOOKUP function consists of an IF formula that uses the value in column B to determine which lookup table to use. The formula in column E simply multiplies the sales amount in column C by the commission rate in column D. The formula in cell E2, for example, is

O N T H E W E B If you prefer to start this chapter with the PivotTable report, in lieu of creating the report from scratch, you can download the ch11_example.xls report shown in Figure 11-2 to your computer from the companion web site at www.wiley.com/go/excelreporting/2007. Look for this document in either the Chap11.zip file or Chap11 directory, depending on which .zip file you download.

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Figure 24-10: Click Apply to test typeface and text size variations when creating your Flash button. 5. Select a typeface from the Font drop-down list. The fonts listed are TrueType fonts found on your system. Most of the button templates have a preselected font and text size. If the preselected font is not found on your system, a small alert appears at the bottom of the dialog box. 6. Enter the font size, in points, in the Size field. 7. If the button is to link to another page, enter the absolute or document-relative URL in the Link field. Alternatively, you can click the Browse button to locate the file. Flash movies don t handle site-root relative links correctly, so your link needs to be either absolute, such as www.idest.com/dreamweaver/, or document-relative. Use document-relative links only if the Flash button is to be stored in the same folder as the page referenced. 8. If you are working in a frame-based site or you want the link to open in another page, select an option from the Target drop-down list. The standard system targets _blank, _self, _parent, and _top are always available. Additional frame names appear if the Flash button is inserted in an existing frameset. 9. If the Flash button is to be placed on a page or in a table with a background color other than white, select the Bg Color swatch to choose an appropriate background. Alternatively, the hexadecimal color number or standard color name may be entered directly into the Bg Color text field. 10. In the Save As text box, enter a path and filename for the Flash button file. If you like, you can use the suggested default name in the site root or click the Browse button to choose a different location.

Figure 1.27 A combinatorial chemistry Grid ( 42).

The triggering timing determines how long to hold the camera button down. This could range from a few milliseconds to a second or two, depending on the camera. I usually set it to 1 second just to be safe. The trigger timing is calculated by the following formula: T2 = 0.693 R2 C T1 and T2 are in seconds, R1 and R2 are in ohms, and C is in farads. For my project, I set R1 to 18800 ohms (four 4700 ohms resistors wired in series), R2 to 300 ohms (three 100 ohms resistors wired in series), and C to 4700 F. With these values, the interval of the timer is 62.210 seconds and the trigger time is 0.977 seconds. These values are close enough to 1minute intervals and holding the camera trigger down for 1 second. To put the interval trigger together, follow the steps from the sections Prototyping the Circuit, Soldering the Wires, and Putting It Together. You ll need to refer to the Making a Delay Trigger section when you wire up the interval trigger (see Figure 1-25). Remember to test your circuit with the LED, as shown in Figure 1-26.

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